apalutamide will minimize the extent or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with drugs that are CYP2C19 substrates may result in lessen publicity to those remedies.enasidenib will raise the level or influence of diazepam by